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Kristian Brock

Principal Biostatistician

UCB

University of Birmingham

Biography

I am a biostatistician specialising in Bayesian and early-phase trial methodology at UCB. I have experience in cancer and non-cancer clinical trials. I have authored several methodology papers and conducted the analysis for several trial results publications. By honourary association, I lead a MSc module on early phase trials at the University of Birmingham and supervise PhDs on trial methodology.

Interests

  • Clinical Trials
  • Early Phase Methodology
  • Bayesian Statistics
  • R
  • Stan

Education

  • PhD in Clinical Trial Methodology, 2019

    University of Birmingham

  • MSc in Statistics, 2011

    University of Sheffield

  • BSc in Mathematics, 2001

    University of London

Projects

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Real data on lots of dose-finding trials

We collected efficacy and toxicity outcomes from 122 published dose-finding trials. This project introduces the data and our insights.

The escalation package

escalation is an R package for dose-escalation clinical trials, providing a consistent, extensible, modular approach.

The PePS2 Trial

PePS2 is a phase II trial of pembrolizumab in performance status 2 non-small-cell lung cancer patients.

The trialr package

trialr is an R package implementing Bayesian clinical trial methods in Stan.

Recent Posts

Sending me data in Excel

If you want to send me data in an Excel sheet, laying it out like this will let me start analysing it right away.

New phase I methods in escalation

Introducing new methods in escalation for TPI, mTPI and Neuenschwander et al.‘s design for phase I trials, plus MCMC-based CRM …

trialr and escalation

The trialr package, the escalation package, how they work together, and how they will grow.

Fetching BibTeX citations using rcrossref

Fetching lots of BibTeX citations is simple using rcrossref

Fitting the Emax Model in R

Emax is an awesome, flexible non-linear model for estimating dose-response curves. Come learn how to fit it in R.

Recent Publications

Pembrolizumab in patients with non-small-cell lung cancer of performance status 2 (PePS2) - a single arm, phase 2 trial

Therapeutic blockade of the axis of programmed cell death 1 (PD-1) and its ligand (PD-L1) has transformed the management of …

A Phase II Clinical Trial Design for Associated Co-primary Efficacy and Toxicity Outcomes with Baseline Covariates

The experimental design presented here is motivated by a phase II clinical trial called PePS2, investigating the efficacy and safety of …

Ibrutinib Plus Venetoclax in Relapsed/Refractory Chronic Lymphocytic Leukemia - The CLARITY Study

The treatment of chronic lymphocytic leukemia (CLL) has been revolutionized by targeted therapies that either inhibit proliferation …

trialr - Bayesian Clinical Trial Designs in R and Stan

This manuscript introduces an R package called trialr that implements a collection of clinical trial methods in Stan and R. In this …

How to design a dose-finding study using the continual reassessment method

The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated dose (MTD) …

Experience

 
 
 
 
 

Principal Biostatistician

UCB

Jul 2020 – Present Slough, UK
I joined UCB as a statistical methodologist in their Centre for Excellence in Statistical Innovation.
 
 
 
 
 

Principal Biostatistician

University of Birmingham

Nov 2018 – Jun 2020 Birmingham, UK

Another promotion at the Cancer Research UK Clinical Trials Unit. The Principal Biostatistician role places an emphasis on leading a programme of research and continuing to win grant funding for new trials. I continued to supervise trials launched in the Senior Biostatistician role, whilst adding a major trial in idiopathic intracranial hypertension. I designed and delivered a 40-hour programme of technical training for new Biostatisticians, and wrote an MSc module on early phase trials.

Highlights

  • Completed PhD.
  • Designed and delivered a MSc module and a technical statistical training programme.
  • Won 1 grant (correct at 2019-12-27) for £1.7m.
  • Published further publications as first-author and co-author.
 
 
 
 
 

Senior Biostatistician

University of Birmingham

Jan 2016 – Nov 2018 Birmingham, UK

Promotion at the Cancer Research UK Clinical Trials Unit to lead biostatistical aspects in a brand new team devoted to early phase trials outside of cancer. The Senior Biostatistician role places a much greater emphasis on designing new trials, winning trial funding, and setting up trials. I served on trials in burns, trauma, amyotrophic lateral sclerosis, inflammatory bowel disease, and Wolfram Syndrome, whilst retaining some involvement in cancer trials.

Highlights

  • Won 7 grants from public bodies and pharma companies totalling £4.3m.
  • Won MRC funding for the first ever RCT in Wolfram Syndrome, a rare monogenic neurodegenerative disorder.
  • Published first publication as first-author, and several publications as co-author.
 
 
 
 
 

Biostatistician

University of Birmingham

Feb 2014 – Jan 2016 Birmingham, UK

As a clinical trial statistician at the Cancer Research UK Clinical Trials Unit, I worked on a range of early phase trials in lung cancer and haematological malignancies. The core responsibilities were to perform trial analyses, produce reports for publication and safety monitoring, and produce documentation in accordance with the trials unit's quality management processes.

Highlights

  • Experience very early in my career on a large, complex platform trial called National Lung Matrix, which investigates targeted therapies in molecularly-defined groups of patients with non-small-cell lung cancer.
  • Experience on dose-finding trials using the Continual Reassessment Method and EffTox designs.
  • Started a PhD on clinical trial methodology.

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