Research

Fitting the Emax Model in R

Emax is an awesome, flexible non-linear model for estimating dose-response curves. Come learn how to fit it in R.

Sample sizes in phase I

Empirically, what sample size is used in dose-escalation trials?

Dataset containing outcomes from dose-finding trials in cancer

Descriptive data and dose-level outcomes from 122 manuscripts reporting results of dose-finding clinical trials in cancer.

Simulation or enumeration with dose-finding designs?

Simulation is the popular approach but brute-force enumeration is more accurate and can even be quicker.

CRM Simulation Checklist

During 2019, I was working on simulations using CRM designs in several different trials. I found I would frequently get the designs mixed up: “We are targeting 20% toxicity in this trial, right? No, that was the other trial…we are targeting 33% here…” Similarly, once or twice, I got to the stage where I wanted to run simulations only to discover we had not specified some important design aspect, like when the trial should stop.