If you want to send me data in an Excel sheet, laying it out like this will let me start analysing it right away.
Emax is an awesome, flexible non-linear model for estimating dose-response curves. Come learn how to fit it in R.
Empirically, what sample size is used in dose-escalation trials?
Descriptive data and dose-level outcomes from 122 manuscripts reporting results of dose-finding clinical trials in cancer.
Simulation is the popular approach but brute-force enumeration is more accurate and can even be quicker.
During 2019, I was working on simulations using CRM designs in several different trials. I found I would frequently get the designs mixed up:
“We are targeting 20% toxicity in this trial, right? No, that was the other trial…we are targeting 33% here…”
Similarly, once or twice, I got to the stage where I wanted to run simulations only to discover we had not specified some important design aspect, like when the trial should stop.