Posts

New phase I methods in escalation

Introducing new methods in escalation for TPI, mTPI and Neuenschwander et al.‘s design for phase I trials, plus MCMC-based CRM …

trialr and escalation

The trialr package, the escalation package, how they work together, and how they will grow.

Fetching BibTeX citations using rcrossref

Fetching lots of BibTeX citations is simple using rcrossref

Fitting the Emax Model in R

Emax is an awesome, flexible non-linear model for estimating dose-response curves. Come learn how to fit it in R.

Sample sizes in phase I

Empirically, what sample size is used in dose-escalation trials?

Dataset containing outcomes from dose-finding trials in cancer

Descriptive data and dose-level outcomes from 122 manuscripts reporting results of dose-finding clinical trials in cancer.

Simulation or enumeration with dose-finding designs?

Simulation is the popular approach but brute-force enumeration is more accurate and can even be quicker.

Dose-paths in the escalation package

Enumerate every possible dose selection decision for all dose-finding models implemented in the escalation package.

PePS2 Results

Results of the PePS2 trial of pembrolizumab in performance status 2 non-small-cell lung cancer patients published in Lancet Respiratory …

Introducing escalation

An R package to unify the interface of dose-escalation models in R. A modular approach that is scalable and extensible.